Table 3.
Mild TBI—need for CT scan.
| Biomarker | #Reports | #Observations | Pooled AUC | Maximum J-statistic |
|---|---|---|---|---|
| A-beta-42 | 1 | 46 | 0.689 | |
| BDNF | 1 | 159 | 0.670 | 0.839 |
| CKBB | 1 | 92 | 0.714 | |
| CRP | 1 | 92 | 0.698 | |
| d-Dimer | 2 | 93 | 0.890 | 0.669 |
| GFAP/GFAP-BDP | 16 | 2040 | 0.831 | 0.936 |
| GM-CSF | 1 | 92 | 0.432 | |
| H-FABP | 2 | 264 | 0.641 | 0.293 |
| IL-10 | 1 | 133 | 0.646 | 0.318 |
| MDA-LDL | 1 | 92 | 0.497 | |
| MMP-2 | 1 | 92 | 0.616 | |
| MT3 | 1 | 306 | 0.590 | |
| NF-H | 1 | 68 | 0.717 | 0.575 |
| NFM | 1 | 52 | 0.605 | 0.211 |
| NRGN | 1 | 494 | 0.510 | |
| NSE | 5 | 844 | 0.798 | 0.690 |
| panel(MMP-2, CRP, CKBB) | 1 | 110 | 0.964 | 0.7190 |
| panel(UCH-L1, GFAP) | 1 | 1947 | 0.986 | 0.9710 |
| S-100B | 30 | 8464 | 0.723 | 0.580 |
| P-Tau | 2 | 350 | 0.921 | 0.944 |
| T-Tau | 6 | 176 | 0.666 | 0.440 |
| P-Tau/T-Tau ratio | 2 | 350 | 0.923 | 0.816 |
| Ubiquitin | 2 | 302 | 0.710 | 0.210 |
| UCH-L1 | 5 | 3108 | 0.700 | 0.470 |
Best results are indicated in boldface. Blank cells = either no data reported in original publication, or pooled AUC was considered too low (below “good” range, <0.80) to calculate J-statistic. See Table 1 for abbreviations.