Table 4.
Mild TBI—delayed recovery.
| Biomarker | #Reports | #Observations | Pooled AUC | Maximum J-statistic |
|---|---|---|---|---|
| BDNF | 1 | 299 | 0.585 | |
| BMX | 1 | 63 | 0.760 | 0.400 |
| CRP | 1 | 846 | 0.615 | 0.330 |
| GFAP | 17 | 1959 | 0.716 | 0.850 |
| Ghrelin | 1 | 118 | 0.829 | 0.659 |
| GSH | 1 | 88 | 0.773 | 0.514 |
| ICAM-1 | 1 | 118 | 0.485 | |
| IL-6 | 1 | 118 | 0.535 | |
| IL-8 | 1 | 118 | 0.615 | |
| NCAM | 1 | 118 | 0.614 | |
| Neuroglobin | 1 | 34 | 0.682 | |
| NFL | 1 | 35 | 0.82 | 0.79 |
| Nogo-A | 1 | 34 | 0.754 | |
| NSE | 6 | 543 | 0.685 | 0.691 |
| pNF-H | 1 | 118 | 0.614 | |
| S-100B | 24 | 2800 | 0.691 | 0.810 |
| E-selectin | 1 | 118 | 0.600 | |
| SNTF | 2 | 73 | 0.863 | 0.750 |
| regulatory T cells | 1 | 40 | 0.592 | |
| Testosterone | 1 | 181 | 0.684 | 0.786 |
| VCAM-1 | 2 | 186 | 0.654 | 0.481 |
| A-Tau | 1 | 56 | 0.87 | 0.77 |
| C-Tau | 1 | 56 | 0.59 | 0.28 |
| P-Tau | 1 | 134 | 0.663 | 0.350 |
| T-Tau | 5 | 335 | 0.640 | 0.863 |
| P-Tau/T-Tau ratio | 1 | 134 | 0.658 | 0.300 |
| UCH-L1 | 7 | 3158 | 0.787 | 0.740 |
Best results are indicated in boldface. Blank cells = either no data reported in original publication, or pooled AUC was considered too low (below “good” range, <0.80) to calculate J-statistic. See Table 1 for abbreviations.