Table 5.
Severe TBI—adverse outcomes.
| Biomarker | #Reports | #Observations | Pooled AUC | Maximum J-statistic |
|---|---|---|---|---|
| Adiponectin | 1 | 86 | 0.785 | 0.604 |
| Base deficit | 1 | 216 | 0.479 | |
| BDNF | ‘ | 170 | 0.482 | |
| Caspase-Cleaved Cytokeratin-18 | 1 | 100 | 0.685 | 0.370 |
| ceruloplasmin | 1 | 20 | 0.800 | 0.600 |
| Cholinesterase | 1 | 188 | 0.381 | 0.519 |
| Copeptin | 4 | 422 | 0.825 | 0.635 |
| Copper | 1 | 20 | 0.795 | 0.590 |
| D-Dimer | 2 | 226 | 0.819 | 0.895 |
| DNA | 2 | 106 | 0.694 | 0.430 |
| FDP | 1 | 1266 | 0.755 | 0.426 |
| Ferritin | 1 | 69 | 0.585 | 0.170 |
| Fibinogen | 1 | 1266 | 0.712 | 0.382 |
| Ficolin-3 | 1 | 384 | 0.823 | 0.619 |
| Galectin-3 | 1 | 300 | 0.808 | 0.553 |
| Gelsolin | 2 | 322 | 0.805 | 0.679 |
| GFAP | 10 | 2448 | 0.749 | 0.800 |
| H-FABP | 1 | 49 | 0.840 | 0.680 |
| HMGB1 | 1 | 106 | 0.882 | 0.657 |
| Hsp70 | 1 | 20 | 0.750 | 0.500 |
| ICAM-1 | 1 | 13 | 0.498 | 0.222 |
| ICAM-5 | 1 | 170 | 0.544 | |
| icORP | 1 | 104 | 0.870 | 0.333 |
| IL-1beta | 1 | 28 | 0.871 | 0.800 |
| IL-6 | 3 | 337 | 0.840 | 0.840 |
| IL-8 | 1 | 20 | 0.835 | 0.67 |
| IL-10 | 1 | 426 | 0.550 | 0.265 |
| INR | 1 | 1266 | 0.738 | 0.394 |
| Leptin | 1 | 284 | 0.875 | 0.649 |
| MBL | 1 | 244 | 0.832 | 0.562 |
| MBP | 2 | 127 | 0.831 | 0.875 |
| MCP-1 | 1 | 170 | 0.677 | |
| MDA | 1 | 100 | 0.760 | 0.370 |
| MIF | 1 | 216 | 0.817 | 0.547 |
| MMP-9 | 1 | 88 | 0.585 | 0.340 |
| Nesfatin | 1 | 300 | 0.786 | 0.487 |
| NF-H | 2 | 200 | 0.760 | 0.552 |
| NFL | 1 | 70 | 0.700 | 0.390 |
| NFM | 1 | 12 | 0.857 | 0.714 |
| NSE | 9 | 911 | 0.715 | 0.905 |
| Periostin | 1 | 130 | 0.815 | 0.506 |
| Platelet count | 1 | 1266 | 0.618 | 0.201 |
| PRDX-6 | 1 | 170 | 0.524 | |
| PTT | 1 | 1266 | 0.748 | 0.410 |
| RDW | 1 | 122 | 0.693 | 0.611 |
| S-100A1B | 1 | 59 | 0.677 | 0.3 |
| S100A12 | 1 | 306 | 0.855 | 0.630 |
| S-100B | 25 | 3712 | 0.762 | 0.880 |
| SCUBE1 | 1 | 113 | 0.831 | |
| Substance P | 1 | 100 | 0.700 | 0.360 |
| SuPAR | 1 | 78 | 0.801 | 0.363 |
| TAC | 1 | 100 | 0.830 | 0.410 |
| Tenascin-C | 1 | 216 | 0.827 | 0.590 |
| Thioredoxin | 1 | 216 | 0.798 | 0.549 |
| thrombospondin-1 | 1 | 402 | 0.827 | 0.619 |
| TIMP-1 | 1 | 100 | 0.645 | 0.290 |
| T-Tau | 6 | 344 | 0.818 | 0.833 |
| UCH-L1 | 5 | 195 | 0.696 | 0.54 |
| VWF | 1 | 44 | 0.660 | 0.32 |
Best results are indicated in boldface. Blank cells = no data reported in original publication; pooled AUC was considered too low (below “good” range, <0.80) to calculate J-statistic. See Table 1 for abbreviations.