Table 4.
Univariate and multivariate analysis of risk factors for treatment failure in organ-space SSI-CRAN
| Univariate and multivariate analysis of risk factors for developing SSI-CRAN | ||||||||
|---|---|---|---|---|---|---|---|---|
| UNIVARIATE | MULTIVARIATE | |||||||
| Non SSI-CRAN (n = 504) | SSI-CRAN (n = 91) | p-value | OR | 95% CI | p-value | |||
| Male, n (%) | 232 | (46) | 42 | (46.2) | 1 | 0.86 | 0.52–1.43 | 0.57 |
| Mean age, years (SD) | 53.1 | (14.3) | 51.4 | (15.3) | 0.26 | 0.99 | 0.97–1.01 | 0.33 |
| > 65 years (%) | 129 | (25.6) | 19 | (20.9) | 0.36 | |||
| Urgent surgery, n (%) | 66 | (13.1) | 13 | (14.3) | 0.74 | |||
| Reason for surgery: | ||||||||
| Intrinsic tumour, n (%) | 203 | (40.3) | 31 | (34.1) | 0.29 | |||
| Extrinsic tumour, n (%) | 97 | (19.2) | 26 | (28.6) | 0.05 | 1.71 | 0.91–3.24 | 0.09 |
| Epilepsy, n (%) | 23 | (4.6) | 0 | (0) | 0.03 | 0 | 0 | 0.99 |
| Vascular, n (%) | 130 | (25.8) | 22 | (24.2) | 0.79 | |||
| Trauma, n (%) | 14 | (2.8) | 3 | (3.3) | 0.73 | |||
| Others, n (%) | 37 | (7.3) | 9 | (9.9) | 0.39 | |||
| Surgical site: | ||||||||
| Supratentorial, n (%) | 386 | (76.6) | 63 | (69.2) | 0.15 | |||
| Infratentorial, n (%) | 49 | (9.7) | 13 | (14.3) | 0.19 | |||
| Retromastoid, n (%) | 69 | (13.7) | 15 | (27.5) | 0.51 | |||
| Duration of surgery, minutes (SD) | 255.2 | (99.6) | 265.9 | (111.4) | 0.65 | |||
| > P75a, n (%) | 124 | (24.6) | 28 | (30.8) | 0.57 | |||
| Mean hospital stay, median (range) | 7 | (5–13) | 7 | (5–31) | 0.59 | |||
| CHARLSON, mean (SD) | 3.14 | (2.3) | 3.03 | (2.2) | 0.70 | 0.90 | 0.78–1.05 | 0.20 |
| < 3, n (%) | 245 | (48.6) | 47 | (51.6) | 0.65 | |||
| 3–5, n (%) | 184 | (36.5) | 30 | (33) | 0.55 | |||
| 6–8, n (%) | 56 | (11.1) | 13 | (14.3) | 0.38 | |||
| > 9, n (%) | 19 | (3.8) | 1 | (1.1) | 0.34 | |||
| ASAb, mean (SD) | 2.3 | (0.7) | 2.4 | (0.8) | 0.08 | |||
| ASA > 2, n (%) | 179 | (35.5) | 44 | (48.4) | 0.025 | 2.26 | 1.32–3.87 | 0.003 |
| NNISc, mean (SD) | 0.9 | (0.7) | 1 | (0.7) | 0.24 | |||
| NNIS I-II, n (%) | 372 | (73.8) | 69 | (75.8) | 0.79 | |||
| Antibiotic prophylaxis: | ||||||||
| Appropriate, n (%) | 432 | (85.7) | 80 | (87.9) | 0.74 | |||
| Inappropriate, n (%) | 59 | (11.7) | 11 | (12.1) | 0.86 | |||
| Non registered, n (%) | 13 | (2.6) | 0 | (0) | 0.23 | |||
| Metal plates, n (%) | 465 | (92.3) | 78 | (85.7) | 0.06 | 1.8 | 0.84–3.87 | 0.13 |
| Use of steroids/chemotherapy, n (%) | 369 | (73.2) | 70 | (76.9) | 0.52 | |||
| Re-intervention, n (%) | 97 | (19.2) | 61 | (67) | < 0.001 | 8.93 | 5.33–14.96 | < 0.001 |
| ICPd sensor, n (%) | 30 | (6) | 6 | (6.6) | 0.81 | |||
| CSFe leak, n (%) | 7 | (1.4) | 4 | (4.4) | 0.72 | 0.85 | 0.21–3.44 | 0.82 |
| Mortality 30d post surgery, n (%) | 31 | (6.2) | 2 | (2.2) | 0.21 | |||
a > 75 percentile of duration of surgery
bAmerican Society of Anaesthesiologists
cNational Nosocomial Infection Surveillance System
dIntracranial pressure
eCerebrospinal fluid