Table 1.
Laboratory and treatment characteristics of the study population
| Parameter | Before KTx | Immediately after KTx | 3 months after KTx | 6 months after KTx | 12 months after KTx | 36 months after KTx |
|---|---|---|---|---|---|---|
| 0 (n = 42) | I (n = 42) | II (n = 42) | III (n = 42) | IV (n = 42) | V (n = 42) | |
| Biochemical markers | ||||||
| Haemoglobin [g/dl] | 12,25 (±3,67) | 10,8 (±3,03) | 13,3 (±3,51) | 13,65 (±3,38) | 13,35 (±3,19) | 14,1 (±3,14) |
| Natrium [mmol/l] | 139,0 (±2,71) | 139,5 (±2,45) | 141,0 (±2,21) | 143,0 (± 2,49) | 141,0 (±2,33) | 142,1 (±2,13) |
| Potassium [mmol/l] | 4,7 (±1,31) | 4,75 (±1,22) | 4,45 (±1,19) | 4,55 (±1,15) | 4,4 (±1,25) | 4,4 (±1,09) |
| Magnesium [mmol/l] | 0,99 (±0,28) | 0,73 (±0,31) | 0,72 (±0,26) | 0,80 (±0,34) | 0,82 (±0,30) | 0,83 (±0,37) |
| Calcium [mmol/l] | 2,54 (±0,24) | 2,42 (±0,27) | 2,55 (±0,35) | 2,6 (±0,29) | 2,6 (±0,41) | 2,52 (±0,32) |
| Phosphorus [mmol/l] | 1,68 (±0,49) | 0,78 (±0,35) | 0,84 (±0,40) | 0,92 (±0,33) | 0,94 (0,42) | 0,97 (±0,43) |
| Ca x P [mg2/dl2] | 52,47 (±13,94) | 23,40 (±8,22) | 26,56 (±7,17) | 29,68 (±7,93) | 30,32 (±6,84) | 30,33 (±7,35) |
| Parathormone [pg/ml] | 734,3 (±656,8) | 169,0 (±132,0) | 130,2 (±102,9) | 113,2 (±90,2) | 108,0 (±101,2) | 97,0 (±88,6) |
| Creatinine [mg/dl] | 6,54 (±2,21) | 1,45 (±0,51) | 1,41 (±0,54) | 1,38 (±0,48) | 1,36 (±0,60) | 1,32 (±0,44) |
| eGRF [ml/min/1,73m2] | 10,9 (±7,6) | 55,6 (±22,9) | 56,9 (±21,2) | 57,5 (±18,8) | 58,72 (±18,3) | 60,4 (±15,3) |
| Urea [mmol/l] | 9,74 (±5,72) | 8,39 (±4,98) | 7,86 (±4,73) | 7,64 (±4,88) | 7,74 (±4,32) | 7,74 (±4,91) |
| Total protein [g/l] | 75,0 (±14,3) | 61,5 (±13,5) | 69,0 (±13,9) | 70,2 (±13,2) | 71,0 (±14,1) | 73,0 (±12,9) |
| Albumin [g/l] | 4,6 (±1,13) | 3,9 (±1,09) | 4,4 (±1011) | 4,43 (±1,17) | 4,45 (±1,21) | 4,47 (±1,08) |
| hs-CRP [mg/l] | 2,12 (±2,22) | 0,76 (±1,20) | 0,7 (±0,93) | 0,66 (±1,39) | 0,84 (±0,95) | 0,74 (±1,08) |
| Total cholesterol [mg/dl] | 219,0 (±67,2) | 218,55 (±44,5) | 205,0 (±40,6) | 195,3 (±45,6) | 195,5 (±50,2) | 197,0 (±52,8) |
| LDL-cholesterol [mg/dl] | 131,0 (±44,15) | 128,0 (±39,6) | 113,3 (±42,9) | 102,5 (±42,6) | 110,5 (±38,5) | 108,0 (±34,2) |
| HDL-cholesterol [mg/dl] | 66,1 (±24,55) | 53,5 (±21,8) | 57,0 (±19,8) | 58,9 (±22,4) | 53,5 (±18,9) | 61,0 (±20,6) |
| Triglycerides [mg/dl] | 214,3 (±67,64) | 201,0 (±60,3) | 183,3 (±64,7) | 164,5 (±58,4) | 153,5 (±55,6) | 126,0 (±52,7) |
| Glucose [mg/dl] | 90,77 (±47,19) | 85,2 (±50,5) | 95,0 (±44,2) | 94,6 (±39,9) | 92,0 (±29,2) | 88,1 (±32,3) |
| Troponin T [μg/l] | 0,018 (±0,037) | 0,022 (±0,011) | 0,014 (±0,021) | 0,013 (±0,015) | 0,016 (±0,021) | 0,014 (±0,024) |
| Myoglobin [ng/ml] | 183,5 (±171,1) | 38,2 (±36,7) | 47,5 (±44,2) | 46,5 (±39,5) | 57,0 (±35,8) | 63,5 (±32,4) |
| Creatine kinase [U/l] | 81,1 (±86,2) | 25,5 (±22,4) | 54,5 (±32,5) | 80,0 (±35,3) | 87,2 (±29,4) | 93,0 (±37,2) |
| Creatine kinase myocardial bound [U/l] | 17,4 (±8,12) | 11,8 (±7,21) | 16,8 (±9,59) | 15,0 (±10,24 | 15,2 (±8,46) | 14,1 (±9,81) |
| Drugs other than immunosuppressants | ||||||
| ACE-inhibitors/sartans [n (%)] | 0 (%) | 0 | 0 | 0 | 0 | 0 |
| Calcium blockers [n (%)] | 40 (95,2%) | 40 (95,2% | 38 (90,4%) | 38 (90,4%) | 36 (85,7%) | 36 (85,7%) |
| Beta-blockers [n (%)] | 23 (54,8%) | 25 (59,5%) | 26 (61,9%) | 24 (57,1%) | 26 (61,9%) | 27 (64,2%) |
| Alfa-blockers [n (%)] | 5 (11,9%) | 6 (14,2%) | 6 (14,2%) | 7 (16,6%) | 5 (11,9%) | 5 (11,9%) |
| Clonidine [n (%)] | 31 (73,8%) | 31 (73,8%) | 30 (71,4%) | 26 (61,9%) | 24 (57,1%) | 20 (47,6%) |
| Diuretic [n (%)] | 40 (95,2%) | 30 (71,4%) | 18 (42,8%) | 10 (23,8%) | 6 (14,2%) | 5 (11,9%) |
| Fibrats [n (%)] | 5 (11,9%) | 8 (19,0%) | 10 (23,8%) | 10 (23,8%) | 10 (23,8%) | 12 (28,5%) |
| Statins [n (%)] | 3 (7,1%) | 10 (23,8%) | 17 (40,4%) | 22 (52,3%) | 22 (52,3%) | 23 (54,7%) |
| Immunosuppressive drugs | ||||||
| Cyclosporine [n (%)] | 21 (50,0%) | 21 (50,0%) | 20 (47,6%) | 18 (42,9%) | 17 (40,5%) | 12 (28,6%) |
| Tacrolimus [n (%)] | 21 (50,0%) | 21 (50,0%) | 22 (52,4%) | 24 (57,1%) | 25 (59,5%) | 30 (71,4%) |
| Mycophenolate mofetil [n (%)] | 42 (100%) | 42 (100%) | 42 (100%) | 42 (100%) | 42 (100%) | 42 (100%) |
| Prednisone [n (%)] | 42 (100%) | 42 (100%) | 42 (100%) | 42 (100%) | 42 (100%) | 42 (100%) |