Table 1.
Cohort Demographic and Clinical Characteristics stratified by body mass index prior to HAART introduction
| Total (n = 1612) |
Underweight (n = 173) |
Normal (n = 1156) |
Overweight/ obese (n = 283) |
p | |
|---|---|---|---|---|---|
| Demographic and Clinical Characteristics | |||||
| Age | 32 (26–44) | 29 (24–39) | 32 (26–44) | 35 (28–45) | < 0.01 |
| Sex | 0.004 | ||||
| Male | 1519 (94.2) | 155 (89.6) | 1102 (95.3) | 262 (92.6) | |
| Female | 93 (5.8) | 18 (10.4) | 54 (4.7) | 21 (7.4) | |
| Marital status | 0.075 | ||||
| Single | 914 (56.8) | 111 (64.2) | 662 (57.3) | 141 (50.0) | |
| Married/Partnered | 483 (30.0) | 45 (26.0) | 342 (29.6) | 96 (34.0) | |
| Divorced/Separated | 196 (12.2) | 14 (8.1) | 140 (12.1) | 42 (14.9) | |
| Widowed | 17 (1.1) | 3 (1.7) | 11 (1.0) | 3 (1.1) | |
| Ethnics | 0.613 | ||||
| Han | 1390 (86.4) | 153 (88.4) | 991 (85.9) | 246 (87.2) | |
| Not Han | 218 (13.6) | 20 (11.6) | 162 (14.1) | 36 (12.8) | |
| Education | 0.255 | ||||
| Less than 9 years | 438 (28.9) | 51 (31.1) | 300 (27.8) | 87 (32.5) | |
| More than 9 years | 1075 (71.1) | 113 (68.9) | 781 (72.2) | 181 (67.5) | |
| Smoking | 0.278 | ||||
| NO | 1000 (62.7) | 112 (65.9) | 723 (63.2) | 165 (58.9) | |
| YES | 594 (37.3) | 58 (34.1) | 421 (36.8) | 115 (41.1) | |
| Alcohol use | 0.104 | ||||
| NO | 843 (53.3) | 102 (61.1) | 594 (52.3) | 147 (52.7) | |
| YES | 738 (46.7) | 65 (38.9) | 541 (47.7) | 132 (47.3) | |
| Transmission route | 0.029 | ||||
| Transfusion | 4 (0.2) | 0 (0.0) | 4 (0.3) | 0 (0.0) | |
| IDU | 6 (0.4) | 2 (1.2) | 2 (0.2) | 2 (0.7) | |
| MSM | 1292 (80.1) | 134 (77.5) | 945 (81.7) | 213 (75.3) | |
| HTS | 182 (11.3) | 20 (11.6) | 128 (11.1) | 34 (12.0) | |
| Unkown | 128 (7.9) | 17 (9.8) | 77 (6.7) | 34 (12.0) | |
| Clinical symptoms | < 0.01 | ||||
| Yes | 231 (14.3) | 51 (29.5) | 157 (13.6) | 23 (8.1) | |
| No | 1360 (84.4) | 121 (69.9) | 980 (84.8) | 259 (91.5) | |
| Unkown | 21 (1.3) | 1 (0.6) | 19 (1.6) | 1 (0.4) | |
| Tuberculosis infection | < 0.01 | ||||
| Yes | 95 (5.9) | 26 (15.0) | 62 (5.4) | 7 (2.5) | |
| No | 1493 (92.7) | 142 (82.1) | 1077 (93.2) | 274 (96.8) | |
| Unkown | 23 (1.4) | 5 (2.9) | 16 (1.4) | 2 (0.7) | |
| WHO stage | < 0.01 | ||||
| I | 1292 (80.2) | 109 (63.0) | 932 (80.7) | 251 (88.7) | |
| II | 66 (4.1) | 7 (4.0) | 54 (4.7) | 5 (1.8) | |
| III | 104 (6.5) | 17 (9.8) | 73 (6.3) | 14 (4.9) | |
| IV | 149 (9.2) | 40 (23.1) | 96 (8.3) | 13 (4.6) | |
| Laboratory Examination | |||||
| Median CD4 (cells/μL) | 243 (139–323) | 183 (40–283) | 243 (144–318) | 271 (181–359) | < 0.01 |
| Median CD8 (cells/μL) | 881 (618–1224) | 738 (509–1058) | 890 (625–1233) | 929 (677–1287) | < 0.01 |
| Median CD4/CD8 ratio | 0.24 (0.15–0.37) | 0.19 (0.07–0.35) | 0.25 (0.15–0.37) | 0.28 (0.18–0.41) | < 0.01 |
| Median viral load (log10copies/mL) | 4.69 (4.25–5.09) | 4.87 (4.35–5.43) (n = 165) | 4.66 (4.25–5.09) (n = 1107) | 4.71 (4.20–4.97) (n = 273) | 0.002 |
| Median TC (mmol/L) | 3.92 (3.45–4.51) | 3.80 (3.40–4.35) | 3.89 (3.43–4.50) | 4.11 (3.61–4.63) | 0.002 |
| Median TG (mmol/L) | 1.22 (0.84–1.73) | 1.03 (0.75–1.45) | 1.18 (0.82–1.67) | 1.57 (1.09–2.24) | < 0.01 |
| Median Glucose (mmol/L) | 5.18 (4.86–5.59) | 4.99 (4.69–5.34) | 5.17 (4.85–5.54) | 5.39 (5.01–5.93) | < 0.01 |
| Median hemoglobin (g/L) | 149 (137–158) | 141 (122–153) | 149 (137–157) | 153 (143–162) | < 0.01 |
HAART highly active antiretroviral therapy, MSM men who have sex with men, HTS heterosexuality, IDU injection drug use, TC total cholesterol, TG triglyceride