Table 3.
Effect of BMI on immune reconstitution outcome of CD4 more than 500cells/μL during the follow-up after antiretroviral therapy
Covariate | HR (95% CI) | p | Adjusted HR (95% CI) | p |
---|---|---|---|---|
Continuous BMI | 1.06 (1.03 to 1.08) | < 0.01 | 1.03 (1.01 to 1.06) | 0.011 |
Sex (female vs male) | 0.78 (0.56 to 1.07) | 0.118 | – | – |
Age | 0.98 (0.97 to 0.98) | < 0.01 | 0.99 (0.98 to 1.00) | 0.004 |
Baseline CD4 (per 100cells/μL increase) | ||||
1–100 | Ref | Ref | ||
101–200 | 3.03 (1.95 to 4.70) | < 0.01 | 2.92 (1.78 to 4.78) | < 0.01 |
201–300 | 10.36 (6.91 to 15.52) | < 0.01 | 10.38 (6.40 to 16.82) | < 0.01 |
301–400 | 25.82 (17.12 to 38.93) | < 0.01 | 25.42 (15.48 to 41.75) | < 0.01 |
401–499 | 56.37 (36.40 to 87.30) | < 0.01 | 52.06 (30.75 to 88.13) | < 0.01 |
CD4/CD8 ratio | 16.07 (11.67 to 22.12) | < 0.01 | 2.47 (1.47 to 4.13) | 0.001 |
Baseline viral load (per log10 increase) (copies/mL) | ||||
≤ 3.00 | Ref | Ref | ||
≥ 6.01 | 0.53 (0.23 to 1.25) | 0.147 | 4.60 (1.90 to 11.16) | 0.001 |
5.01–6.00 | 0.83 (0.44 to 1.57) | 0.569 | 2.62 (1.37 to 4.99) | 0.004 |
4.01–5.00 | 1.22 (0.65 to 2.28) | 0.540 | 1.97 (1.05 to 3.72) | 0.035 |
3.01–4.00 | 1.53 (0.80 to 2.92) | 0.201 | 1.68 (0.87 to 3.22) | 0.120 |
WHO stage | ||||
I | Ref | Ref | ||
II | 0.41 (0.27 to 0.63) | < 0.01 | 0.62 (0.40 to 0.97) | 0.037 |
III | 0.34 (0.23 to 0.51) | < 0.01 | 0.67 (0.44 to 1.04) | 0.074 |
IV | 0.22 (0.14 to 0.33) | < 0.01 | 1.09 (0.68 to 1.75) | 0.736 |
Drinking (yes vs no) | 1.04 (0.90 to 1.20) | 0.593 | – | – |
Race (not Han vs Han) | 0.98 (0.79 to 1.21) | 0.834 | – | – |
CI confidence intervals, HR hazard ratios, Ref reference