Table 3.

Telomere fusions accumulate in DNA-PKcs-deficient kidney cells

Genotypes*	Cell analyzed	Aneuploid (%)	Total fusions (% mean ± S.E.)	Fusions with TTAGGG repeats† (% mean ± S.E.)	Fragments (%)	Breaks (%)
						Chromosome	Chromatid
+/+	50	1 (2.0)	0 (0)	0 (0)	1 (2.0)	0 (0)	0 (0)
+/+	52	1 (1.9)	0 (0)	0 (0)	0 (0)	0 (0)	0 (0)
+/−	56	9 (16.1)	1 (1.8  ± 1.8)	1 (1.8  ± 1.8)‡	5 (8.9)	0 (0)	1 (1.8)
+/−	55	14 (25.5)	2 (3.6  ± 2.5)	2 (3.6  ± 2.5)‡	8 (14.5)	1 (1.8)	0 (0)
−/−	58	21 (36.2)	16 (27.6  ± 6.9)	12 (20.7  ± 6.4)§	12 (20.7)	3 (5.2)	2 (3.5)
−/−	61	30 (49.2)	18 (29.5  ± 6.8)	18 (29.5  ± 6.8)§	8 (13.1)	3 (4.9)	1 (1.6)

^*Independently isolated littermates. 

^† Number of fusions with telomeres at the fusion point. These values are included in the total fusions column. 

^‡ Comparison between all lines of wild-type and +/− MEFs; P value = 0.28. 

^§ Comparison between all lines of wild-type and −/− MEFs; P value = 1.5 × 10⁻⁷.