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. 2019 May 2;16:27. doi: 10.1186/s12986-019-0353-8

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — miR-499/Sox6 axis is involved in inducing fast-to-slow fiber type transition by myricetin. After transfected with inhibitor or mimic of miR-499, the mRNA expressions of miR-499 (a), Myh7b (b), Myh7 (c), Sox6 (d), Myh1 (e), and Myh4 (f) in L6 myotubes were determined. Protein levels (g) of Myh7 and Sox6 were measured by immunoblotting. The mRNA (h) and protein (i) levels of PGC-1α were monitored in the transfected L6 myotubes. Oxygen consumption rates (OCR) of myotubes (j) were determined by Seahorse XFp metabolic flux analysis. Basal respiration, ATP production and maximal respiration (k) were analyzed. Data are presented as mean ± SD. *P<0.05, **P<0.01, ***P<0.001