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. 2019 May 3;12:27. doi: 10.1186/s13072-019-0272-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 11 — Examples of clusters of predicted cis-regulatory sites in Mip promoter and its proximal and distal enhancers. a Mip locus and its promoter and two enhancers (− 0.6 kb proximal and − 8 kb distal). b Experimentally validated (Pitx3 and Sp1) and predicted (Hsf4, MafK, Smad, and Sox) grammar of the Mip promoter and enhancers. M, H, and C show DNA sequences from mouse, human, and cow, respectively