Fig. 9.

Motif and functional analysis of Pax6 binding sites with two chromatin patterns at P0.5 lens. a Heat map shows signals of ChIP-seq and ATAC-seq within 5 kb from Pax6 peak centers at open chromatin regions in P0.5 lens epithelium (Pax6 + P0.5 epi + P0.5 fiber-) and at both P0.5 lens epithelial and fiber open chromatin regions (Pax6 + P0.5 epi + P0.5 fiber +). b Pie charts show the genomic distributions of the two groups of Pax6 peaks. c Dot plots show the enriched GO terms for the two groups of Pax6 peaks. The dot color represents –log10(FDR), and the dot size represents number of regions in the GO terms. d Top enriched motifs inside the groups