Table 3.
Univariate and multivariate analysis of prognostic factors for overall survival
| Characteristic | OS (months) | P (univariate analysis) | P (multivariate analysis) | Hazard ratio (95% CI) |
|---|---|---|---|---|
| Age (years) | ||||
| <50 | 12.06 | 0.021 | 0.134 | 0.66 (0.377-1.139) |
| ≥50 | 21.42 | |||
| Degree of differentiation (n=3) | ||||
| PDAC | 12.65 | 0.481 | - | |
| MDAC/WDAC | 16.66 | |||
| Signet ring histology | ||||
| Present | 10.22 | 0.010 | 0.021 | 1.46 (1.060-2.015) |
| Absent | 18.73 | |||
| Baseline elevated CEA | ||||
| Yes | 13.7 | 0.343 | - | |
| No | 23.10 | |||
| ECOG PS | ||||
| 0,1 | 14.16 | 0.888 | - | |
| ≥2 | 16.40 | |||
| Baseline obstruction | ||||
| Present | 15.70 | 0.392 | - | |
| Absent | 22.77 | |||
| Resectability status at baseline | ||||
| Potentially resectable | 32.62 | 0.016 | 0.027 | 1.95 (1.080-3.511) |
| Unresectable | 13.04 |
ECOG PS=Eastern oncology group performance status, PDAC=Poorly differentiated adenocarcinoma, MDAC=Moderately differentiated adenocarcinoma, WDAC=Well differentiated adenocarcinoma, CI=Confidence interval, OS=Overall survival, CEA=Carcinoembryonic antigen