Table 1.
Regression results for effects of age (mean centered) on D2-like receptor availability (BPND) from studies using [18F]Fallypride on the DSTE and [11C]FLB457 on the HRRT.
| Fallypride |
FLB |
||||
|---|---|---|---|---|---|
| Region | Intercept | Age slope | Intercept | Age slope | |
| Thalamus | unc | 1.95* (1.88, 2.03) | −0.009* (−0.013, −0.004) | 3.15* (2.97, 3.33) | −0.008 (−0.019, 0.003) |
| PVC | 2.40* (2.31, 2.49) | −0.008* (−0.013, −0.003) | 3.51* (3.30, 3.71) | −0.008 (−0.020, 0.004) | |
| ACC | unc | 0.57* (0.53, 0.61) | −0.005* (−0.007, −0.003) | 1.01* (0.91, 1.10) | −0.009* (−0.015, −0.004) |
| PVC | 0.70* (0.65, 0.76) | −0.003* (−0.006, 0.000) | 1.19* (1.08, 1.30) | −0.010* (−0.017, −0.004) | |
| MTL | unc | 1.10* (1.06, 1.15) | −0.004* (−0.007, −0.002) | 1.26* (1.17, 1.35) | −0.006* (−0.011, 0.000) |
| PVC | 1.50* (1.43, 1.56) | −0.002 (−0.006, 0.002) | 1.45* (1.33, 1.57) | −0.007 (−0.014, 0.000) | |
| Temporal Cortex | unc | 0.70* (0.65, 0.75) | −0.005* (−0.008, −0.002) | 1.35* (1.22, 1.47) | −0.013* (−0.020, −0.006) |
| PVC | 1.13* (1.06, 1.20) | −0.005* (−0.009, −0.001) | 1.68* (1.52, 1.83) | −0.014* (−0.023, −0.004) | |
| Striatum | unc | 19.11* (18.47, 19.74) | −0.102* (−0.140, −0.065) | ||
| PVC | 29.77* (28.77, 30.76) | −0.136* (−0.194, −0.078) | |||
| Frontal Cortex | unc | 0.77* (0.69, 0.85) | −0.008* (−0.013, −0.003) | ||
| PVC | 0.93* (0.83, 1.03) | −0.007* (−0.013, −0.001) | |||
| Parietal cortex | unc | 0.83* (0.73, 0.92) | −0.009* (−0.014, −0.003) | ||
| PVC | 0.98* (0.86, 1.10) | −0.010* (−0.017, −0.003) | |||
Note: Unstandardized effects reported with 95% CIs.
unc: uncorrected; PVC: partial volume corrected; HRRT: high resolution research tomograph; DSTE: discovery STE; ACC: anterior cingulate cortex; MTL: medial temporal lobe.
*
Significant at p < .05, two-tailed.