Table 3.
Study Endpoints.
| TKI |
P Within Group | TKI + WE |
P Within Group | Change Score, Between Group |
||||
|---|---|---|---|---|---|---|---|---|
| Baseline | Endpoint | Baseline | Endpoint | (95% CI) | P | |||
| Patient | ||||||||
| FACT-L scale | ||||||||
| PWB | 21.8 ± 5.3 | 16.9 ± 7.1 | .052 | 21.4 ± 5.3 | 17.4 ± 5.7 | .089 | 0.08 (−0.02 to 0.22) | .103 |
| SWB | 19.7 ± 5.0 | 18.9 ± 6.2 | .065 | 19.3 ± 3.8 | 17.1 ± 5.5 | .078 | 0.11 (−0.08 to 0.16) | .122 |
| EWB | 16.1 ± 5.1 | 15.6 ± 5.9 | .050 | 18.9 ± 6.0 | 12.8 ± 5.7 | .037 | 1.44 (0.75 to 2.13) | .014 |
| FWB | 17.5 ± 6.7 | 14.9 ± 6.3 | .077 | 14.1 ± 5.8 | 13.1 ± 5.4 | .07 | 0.52 (−0.41 to 1.46) | .098 |
| LCS | 19.3 ± 3.8 | 19.4 ± 5.7 | .151 | 20.4 ± 5.1 | 17.4 ± 5.7 | .09 | 1.60 (−1.34 to 1.62) | .159 |
| TOI | 57.6 ± 12.5 | 58.4 ± 12.6 | .105 | 56.2 ± 10.8 | 44.6 ± 10.6 | .021 | 1.38 (−0.96 to 3.72) | .123 |
| HADS | ||||||||
| Anxiety subscale | 10.4 ± 3.1 | 7.6 ± (3.0) | .041 | 10.4 ± 3.1 | 6.1 ± (2.2) | .022 | 1.9 (0.6 to 3.3) | .030 |
| Depression subscale | 10.5 ± 3.6 | 6.8 ± (5.8) | .034 | 10.5 ± 3.6 | 5.8 ± (3.5) | .039 | 0.50 (−0.46 to 1.46) | .221 |
| Caregiver | ||||||||
| CQOLC | ||||||||
| Burden | 55.9 ± 17.3 | 50.9 ± 7.3 | ≥.05 | 54.6 ± 12.1 | 44.6 ± 10.7 | .039 | 1.5 (0.6 to 3.3) | .077 |
| Disruptiveness | 76.5 ± 20.7 | 71.5 ± 22.7 | ≥.05 | 79.7 ± 22.4 | 57.7 ± 20.9 | .027 | 3.4 (2.5 to 4.3) | .057 |
| Adaptation | 65.7 ± 13.7 | 54.7 ± 11.7 | .028 | 63.6 ± 19.7 | 46.4 ± 18.7 | .011 | 6.7 (5.3 to 8.2) | .037 |
| Financial | 67.8 ± 21.9 | 69.8 ± 11.9 | ≥.05 | 76.8 ± 14.5 | 70.8 ± 19.3 | .141 | 5.9 (4.4 to 7.3) | .044 |
| FES-CV | ||||||||
| Cohesion | 5.1 ± 1.6 | 5.7 ± 1.7 | ≥.05 | 5.6 ± 2.7 | 7.3 ± 1.8 | .027 | 0.07 (0.04 to 0.12) | .021 |
| Conflict | 4.9 ± 1.9 | 4.5 ± 1.7 | ≥.05 | 4.5 ± 2.8 | 3.4 ± 1.9 | .041 | 1.08 (0.14 to 0.77) | .031 |
| Expressiveness | 4.1 ± 1.8 | 4.7 ± 2.2 | ≥.05 | 4.2 ± 1.9 | 4.1 ± 1.8 | .056 | 0.03 (0.21 to 0.91) | .056 |
Abbreviations: TKI, tyrosine kinase inhibitor; WE, wellness education; CI, confidence interval; FACT-L, Functional Assessment of Cancer Therapy–Lung; PWB, physical well-being; SWB, social well-being; EWB, emotional well-being; FWB, functional well-being; LCS, lung cancer subscale; TOI, Trial Outcome Index; HADS, Hospital Anxiety and Depression Scale; CQOLC, Caregiver QOL Index–Cancer Scale; FES-CV, Family relationship Chinese version of the Family Environment Scale.
Note: The significance of values in bold in table 3 are all P<0.05.