Table 3.
Univariate and Multivariate Analyses by Cox Proportional Hazard Ratio Model for Mortality.
| Unadjusted Univariate Analysis | Adjusted Multivariate Analysis | |||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| BMI (BMI <20.0 vs ≥20.0) | 1.96 (1.13-3.41) | .015* | ||
| ECOG-PS (3-4 vs 0-2) | 4.34 (2.30-8.18) | <.001* | 2.51 (1.16-5.44) | .020* |
| Leukocytosis (WBC >10 000 vs ≤10 000) | 5.16 (2.60-10.22) | <.001* | 2.65 (1.19-5.92) | .017* |
| Inflammation (CRP >1.0 vs ≤1.0) | 2.44 (1.42-4.20) | .001* | ||
| Anemia (Hb <10.0 vs ≥10.0) | 2.09 (1.00-4.37) | .046* | ||
| Hyponatremia (Na <130.0 vs ≥130.0) | 2.47 (1.11-5.51) | .027* | — | — |
| Hypoalbuminemia (albumin <3.0 vs ≥3.0) | 5.16 (2.88-9.25) | <.001* | ||
| Bilirubinemia (Bilirubin >1.0 vs ≤1.0) | 1.64 (0.87-3.07) | .123 | — | — |
| Fluid retention (presence vs absence) | 5.40 (3.05-9.56) | <.001* | 2.17 (1.05-4.49) | .038* |
| Malnutrition (presence vs absence) | 2.60 (1.32-5.11) | .006* | ||
| E/I ratio (<1.0 vs ≥1.0) | 3.52 (2.01-6.16) | <.001* | 3.49 (1.75-6.96) | <.001* |
Abbreviations: HR, hazard ratio; CI, confidence interval; BMI, body mass index; ECOG-PS, Eastern Cooperative Oncology Group performance status; WBC, white blood cell count; CRP, C-reactive protein; Hb, hemoglobin; E/I, extracellular-to-intracellular fluid volume.
*
Indicates that the P was statistically significant (P < .05).