Table 1.
First 20 known genes expressed highly in HCC and corresponding noncancerous liver (non-HCC), respectively, from EST sequencing
| HCC
|
Non-HCC
|
||
|---|---|---|---|
| Gene name | Copies, %* | Gene name | Copies, %* |
| Hs.75442 (serum albumin)†‡ | 1,007 (5.87) | Hs.75442 (serum albumin)†‡ | 1,226 (7.51) |
| Hs.75621 (α1-antitrypsin)† | 180 (1.05) | Hs.75431 (fibrinogen, γ polypeptide)†‡ | 275 (1.68) |
| Hs.76177 (inter-α-trypsin inhibitor)†‡ | 125 (0.73) | Hs.75621 (α-1-antitrypsin)† | 202 (1.24) |
| Hs.237658 (apolipoprotein AII)‡ | 102 (0.60) | Hs.234234 (aldolase B)†‡ | 194 (1.19) |
| Hs.75431 (fibrinogen, γ-polypeptide)†‡ | 86 (0.50) | Hs.3314 (selenoprotein P)†‡ | 167 (1.02) |
| Hs.278693 (TI-227H)†‡ | 86 (0.50) | Hs.7645 (fibrinogen β-chain)†‡ | 138 (0.84) |
| Hs.75615 (apolipoprotein C-II)†‡ | 85 (0.50) | Hs.278693 (TI-227H)†‡ | 120 (0.73) |
| Hs.3314 (selenoprotein P)†‡ | 78 (0.46) | Hs.1219 (ADH4 gene for class II alcohol dehydrogenase)‡ | 100 (0.61) |
| Hs.7645 (fibrinogen β-chain)†‡ | 67 (0.39) | Hs.1870 (phenylalanine hydroxylase)‡ | 87 (0.53) |
| Hs.234234 (aldolase B)†‡ | 66 (0.39) | Hs.76177 (inter-α-trypsin inhibitor)†‡ | 87 (0.53) |
| Hs.76415 (PK-120)‡ | 57 (0.33) | Hs.75183 (cytochrome P-450j)†‡ | 79 (0.48) |
| Hs.75430 (α-2-HS-glycoprotein)†‡ | 55 (0.32) | Hs.4 (alcohol dehydrogenase β-1-subunit)‡ | 68 (0.42) |
| Hs.73742 (ribosomal protein, large, P0)†‡ | 54 (0.32) | Hs.75335 (L-arginine:glycine amidinotransferase)‡ | 66 (0.40) |
| Hs.156110 (IgG)‡ | 50 (0.29) | Hs.75155 (transferrin)† | 57 (0.35) |
| Hs.118162 (fibronectin)† | 49 (0.29) | Hs.1252 (apolipoprotein H)† | 54 (0.33) |
| Hs.111334 (ferritin, light polypeptide)‡ | 48 (0.29) | Hs.75615 (apolipoprotein C-II)†‡ | 52 (0.32) |
| Hs.155421 (α-fetoprotein)‡ | 45 (0.26) | Hs.118162 (fibronectin)† | 51 (0.31) |
| Hs.79037 (chaperonin 10)‡ | 42 (0.25) | Hs.50966 (carbamyl phosphate synthetase I)‡ | 47 (0.29) |
| Hs.169401 (apolipoprotein E)‡ | 41 (0.24) | Hs.1504 (hemopexin)‡ | 46 (0.28) |
| Hs.75155 (transferrin)† | 40 (0.23) | Hs.76053 (RNA helicase p68)‡ | 45 (0.27) |
*
Percentage of a given EST in all ESTs obtained from that of cDNA libraries.
†
The gene was hit concurrently in the list of the first 50 genes expressed highly in both HCC and non-HCC from EST sequencing.
‡
Significant differences of gene expression (P < 0.05) between HCC and non-HCC by statistical analysis (http://igs-server.cnrs-mrs.fr).