Table 2.

Alteration of hepatocellular function at the transcript level in HCC^*

Categories	Key enzyme/protein	Alteration
Glysometabolism
Glycolysis	6-phosphofructokinase-1	↑
Glyconeogenesis	Glucose-6-phosphatase	↓
	Pyruvate carboxy kinase 1	↓
	Fructose-1,6-biphosphatase	↓
Respiratory chain	NADH dehydrogenase Fe-S protein 8	↓
	NADH dehydrogenase 1 α subcomplex	↓
	NADH dehydrogenase Fe-S protein 6	↓
	Pyruvate dehydrogenase 1	↓
Glycogen synthesis	Galactokinase 1	↓
	Galactokinase 2	↓
	Aldolase B, fructose-bisphosphate	↓
	Uridine diphospho glucose pyrophosphorylase 2	↓
	Glycogen synthase 2	↓
Amino acid metabolism	Leucine aminopeptidase	↑
	Alanine:glyoxylate aminotransferase	↑
	Carbamyl phosphate synthetase I	↓
	Phenylalanine hydroxylase	↓
	Kynurenine 3-hydroxylase	↓
	Ornithine decarboxylase	↓
Protein metabolism	Prealbumin	↓
	Serum albumin	↓
	Transferrin	↓
	Fibrinogen α chain	↓
	Fibrinogen β chain	↓
	α-1 type XVI collagen	↓
	α-1 type XVI collagen	↓
	Antithrombin III	↓
	Coagulation factor XIII	↓
	Ceruloplasmin	↓
	C-reactive protein	↓
	Ferritin H	↑
	α-fetoprotein	↑
Lipid metabolism	Acyl-coenzyme A:cholesterol acyltransferase 1	↓
	7-Dehydrocholesterol reductase	↓
	CTP:phosphocholinecytidyl transferase	↓
	Acyl-CoA dehydrogenase	↓
	Fatty acid synthase	↓
Nucleic acid metabolism	Adenosine deaminase	↑
Biotransformation	Cytochrome P450-IIB	↓
	Cytochrome P450 IIC	↓
	Cytochrome P450c 17	↓
	Cytochrome P450 IIE1	↓
	P450 mRNA encoding nifedipine oxidase	↓
	Cholesterol side chain cleavage enzyme P450	↓
	Lanosterol 14-demethylase cytochrome P450	↓
	Glutathione S-transferase θ1	↓
	Glutathione S-transferase	↓
	Glutathione S-transferase μ3	↓
	Glutathione S-transferase θ2	↓
	Monoamine oxidase A	↓
	Chlordecone reductase	↓
	Dihydropteridine reductase	↓
	ζ-crystallin/quinone reductase	↓
	Ubiquinol-cytochrome c reductase subunit	↓

^*The data were integrated from ESTs and cDNA array data with statistically significant differences or more than 2-fold between HCC and non-HCC.