Table 2.

Mitochondrial angiopathy on electronmicroscopy in m.3243A>G patients

	REF
Mitochondrial accumulation in smooth muscle and endothelial cells	Ohama et al 198864
Tunica media cell degeneration and necrosis
Endothelial cell hypertrophy	Kishi et al 198842
Increased number subendothelial mitochondria
Narrowing capillary lumens
Marked aggregation of mitochondria in smooth muscle cells and vascular endothelium	Mizukami et al. 199256
Proliferation of capillary vessels	Bertrand et al. 19967
Vascular sclerosis	Prayson and Wang 198867