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. 2019 Apr 26;9:314. doi: 10.3389/fonc.2019.00314

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Copyright © 2019 Nourmohammadi, Aung, Cui, Pei, De Ieso, Harata-Lee, Qu, Adelson and Yool.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Identification of significantly perturbed pathways using SPIA analysis. (A) 101 significantly perturbed pathways in MDA-MB-231 treated by CKI 2 mg/ml were observed. Total perturbation values are shown on the x-axis, and pathway IDs are on the y-axis. The global perturbation P-value (pG < 0.05) was used. (B) Significantly perturbed “focal adhesion” pathway in MDA-MB-231 treated by CKI 2 mg/ml. (C) Significantly perturbed “regulation of actin cytoskeleton” pathway in MDA-MB-231 treated by CKI 2 mg/ml. Up- and down-regulated genes are shown in red and green, respectively and genes that were not affected by CKI treatment are shown in white or gray. (D) 14 “core genes” that are found across three different datasets (see Methods).