Table 5.
Association between Genotypes and Peripheral Drusen and Pigment for Grades 1 and 2
| Genotype | Peripheral Drusen | Reticular Pigment | ||||
|---|---|---|---|---|---|---|
| n (%) | OR (CI) | n (%) | OR (CI) | |||
| CFHY402H: rs1061170 (Y402H) | ||||||
| TT | 14/354 (4) | 1.0 | 33/352 (9) | 1.0 | ||
| CT | 46/567 (8) | 2.2 (1.0–4.9) | 89/563 (16) | 1.9 (1.1–3.4) | ||
| CC | 19/245 (8) | 2.0 (0.8–5.1) | 48/241 (20) | 2.4 (1.2–4.7) | ||
| P (trend) | 0.11 | 0.006 | ||||
| CFH: rs1410996 | ||||||
| TT | 4/140 (3) | 1.0 | 11/138 (8) | 1.0 | ||
| CT | 39/514 (8) | 2.7 (0.7–9.5) | 75/508 (15) | 1.9 (0.8–4.7) | ||
| CC | 33/496 (7) | 2.2 (0.6–8.0) | 83/495 (17) | 2.2 (0.9–5.3) | ||
| P (trend) | 0.52 | 0.010 | ||||
| LOC387715: rs10490924 (A69S) | ||||||
| GG | 47/577 (8) | 1.0 | 95/569 (17) | 1.0 | ||
| GT | 20/456 (4) | 0.5 (0.2–1.1) | 65/454 (14) | 0.9 (0.5–1.4) | ||
| TT | 8/109 (7) | 1.0 (0.4–2.6) | 6/107 (8) | 0.3 (0.1–1.0) | ||
| P (trend) | 0.37 | 0.055 | ||||
| C2: rs9332739 (E318D) | ||||||
| GG | 71/1013 (7) | 1.0 | 149/1003 (15) | 1.0 | ||
| CG/CC | 5/122 (4) | 0.6 (0.2–2.0) | 17/122 (14) | 0.9 (0.4–1.9) | ||
| P (trend) | 0.38 | 0.8 | ||||
| CFB: rs641153 (R32Q) | ||||||
| CC | 63/953 (7) | 1.0 | 139/943 (15) | 1.0 | ||
| CT/TT | 15/191 (8) | 1.2 (0.5–2.6) | 26/191 (14) | 0.9 (0.5–1.6) | ||
| P (trend) | 0.68 | 0.65 | ||||
| C3: rs2230199 (R102G) | ||||||
| CC | 40/535 (7) | 1.0 | 76/533 (14) | 1.0 | ||
| CG | 24/449 (5) | 0.7 (0.3–1.3) | 66/441 (15) | 1.0 (0.6–1.7) | ||
| GG | 6/79 (8) | 1.0 (0.3–3.1) | 8/79 (10) | 0.6 (0.2–1.8) | ||
| P (trend) | 0.51 | 0.59 | ||||
The eye was the unit of analysis. OR (odds ratio) adjusted for AMD grade.