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. 2019 Apr 26;10:877. doi: 10.3389/fimmu.2019.00877

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Copyright © 2019 Degos, Heinemann, Barrou, Boucherit, Lambaudie, Savina, Gorvel and Olive.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cytokines and chemokines profile is different between the tumor and the healthy adjacent tissue, regulating NK cells differently. (A) The presence of TNF-α, IFN-γ, IL-6, IL-1β, and IL-15 in the supernatant of the tissue dissociation was assessed by Luminex and compared between the tumor (black bars, n = 11) and the healthy adjacent tissue (white bars). (B) The presence of the following chemokines in the tumor microenvironment (black bars) was compared to the ones found in the healthy adjacent tissue (white bars, n = 11): CXCL12, CCL21, CXCL11, IP-10, CCL19, and CCL27. Mean ± SEM of different patients' samples, *p < 0.05, **p < 0.01.