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. 2019 Apr 26;10:867. doi: 10.3389/fimmu.2019.00867

Figure 2.

Figure 2

Representative images showing PD-L1 (A–D), SEMA4D (E–H), and VEGF (I–L) expressions. (A) PD-L1 negative expression in serous ovarian adenocarcinoma (G3, FIGO Stage II) (200 ×); (B) serous ovarian adenocarcinoma (G3, FIGO Stage III) with immunostaining of PD-L1 in the membrane of cancer cells (200 ×; Evaluation: 3 points); (C) serous ovarian adenocarcinoma (G3, FIGO Stage III) with immunostaining of PD-L1 in the membrane and cytoplasm of cancer cells (200 ×; Evaluation: 5 points); (D) serous ovarian adenocarcinoma (G3, FIGO Stage IV) with immunostaining of PD-L1 (200 ×; Evaluation: 5 points); (E) serous ovarian adenocarcinoma (G2, FIGO Stage III) with immunostaining of SEMA4D (200 ×; Evaluation: 2 points); (F) ovarian clear cell carcinoma (G3, FIGO Stage III) with immunostaining of SEMA4D (200 ×; Evaluation: 3 points); (G) endometrioid ovarian adenocarcinoma (G2, FIGO Stage II) with immunostaining of SEMA4D in the membrane of cancer cells (200 ×; Evaluation: 5 points); (H) serous ovarian adenocarcinoma (G3, FIGO Stage III) with immunostaining of SEMA4D in the membrane of cancer cells (200 ×; Evaluation: 5 points); (I) serous ovarian adenocarcinoma (G3, FIGO Stage II) with negative immunostaining of VEGF (200 × ); (J) serous ovarian adenocarcinoma (G3, FIGO Stage II) with immunostaining of VEGF in the cytoplasm of cancer cells (200 ×; Evaluation: 3 point); (K) serous ovarian adenocarcinoma (G3, FIGO Stage III) with immunostaining of VEGF (200 ×; Evaluation: 5 points); (L) serous ovarian adenocarcinoma (G3, FIGO Stage III) with immunostaining of VEGF (400 ×; Evaluation: 7 points).