Table 3.
Univariate and multivariate Cox regression analyses to assess the prognostic factors of OS
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Male | 1.193 (0.701–2.029) | 0.515 | ||
| Age | 1.051 (1.018–1.085) | 0.002 | 1.045 (1.010–1.081) | 0.011 |
| Smoking history | 1.752 (1.028–2.986) | 0.039 | 1.521 (0.864–2.678) | 0.146 |
| BMI | 1.000 (0.913–1.096) | 0.996 | ||
| Hypertension | 0.798 (0.429–1.487) | 0.478 | ||
| Diabetes mellitus | 0.292 (0.071–1.198) | 0.087 | ||
| COPD | 1.702 (0.878–3.301) | 0.115 | ||
| CHD | 1.317 (0.411–4.218) | 0.643 | ||
| Emphysema | 1.923 (1.032–3.586) | 0.040 | 1.263 (0.653–2.442) | 0.487 |
| Preoperative lung function | ||||
| FEV1 | 0.690 (0.452–1.054) | 0.086 | ||
| FVC | 0.758 (0.533–1.080) | 0.125 | ||
| FEV1/FVC | 0.993 (0.970–1.016) | 0.538 | ||
| Tumor location (left) | 1.040 (0.600–1.803) | 0.888 | ||
| Tumor size | 1.196 (1.006–1.421) | 0.043 | 0.990 (0.814–1.205) | 0.921 |
| Histology | 1.113 (0.700–1.771) | 0.650 | ||
| Lobectomy | 1.511 (0.811–2.816) | 0.194 | ||
| TNM stage II | 1.882 (0.948–3.737) | 0.071 | ||
| Preoperative albumin | 0.875 (0.811–0.945) | 0.001 | 1.018 (0.949–1.093) | 0.610 |
| Preoperative globulin | 1.096 (1.045–1.149) | <0.001 | 0.966 (0.887–1.052) | 0.422 |
| AGR<1.51 | 4.304 (2.425–7.638) | <0.001 | 3.424 (1.600–7.331) | 0.002 |
Abbreviations: OS, overall survival; BMI, body mass index; COPD, chronic obstructive pulmonary disease; CHD, coronary heart disease; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; TNM, tumor-node-metastasis; AGR, albumin–globulin ratio.