Table 4.
Univariate and multivariate Cox regression analyses to assess the prognostic factors of DFS
| Characteristics | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P-value | HR (95%CI) | P-value | |
| Male | 1.281 (0.754–2.175) | 0.360 | ||
| Age | 1.028 (0.997–1.061) | 0.078 | ||
| Smoking history | 1.665 (0.983–2.821) | 0.058 | ||
| BMI | 1.015 (0.928–1.109) | 0.749 | ||
| Hypertension | 1.375 (0.790–2.390) | 0.260 | ||
| Diabetes mellitus | 0.626 (0.226–1.732) | 0.367 | ||
| COPD | 2.071 (1.113–3.854) | 0.022 | 1.166 (0.546–2.490) | 0.691 |
| CHD | 1.776 (0.642–4.912) | 0.268 | ||
| Emphysema | 2.118 (1.156–3.880) | 0.015 | 1.876 (0.898–3.919) | 0.094 |
| Preoperative lung function | ||||
| FEV1 | 0.764 (0.498–1.172) | 0.218 | ||
| FVC | 0.824 (0.577–1.176) | 0.287 | ||
| FEV1/FVC | 0.995 (0.971–1.020) | 0.689 | ||
| Tumor location (left) | 1.124 (0.647–1.955) | 0.678 | ||
| Tumor size | 1.319 (1.131–1.539) | <0.001 | 1.211 (1.011–1.450) | 0.038 |
| Histology | 1.325 (0.835–2.101) | 0.232 | ||
| Lobectomy | 2.372 (1.197–4.701) | 0.013 | 1.844 (0.899–3.782) | 0.095 |
| TNM stage II | 1.748 (0.882–3.465) | 0.110 | ||
| Preoperative albumin | 0.964 (0.895–1.038) | 0.327 | ||
| Preoperative globulin | 1.056 (1.002–1.114) | 0.043 | 0.978 (0.896–1.068) | 0.627 |
| AGR<1.51 | 2.426 (1.427–4.124) | 0.001 | 2.177 (1.052–4.508) | 0.036 |
Abbreviations: DFS, disease-free survival; BMI, body mass index; COPD, chronic obstructive pulmonary disease; CHD, coronary heart disease; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; TNM, tumor-node-metastasis; AGR, albumin–globulin ratio.