Table 2.
Effects of resistance training (RT) on body composition, muscle function, in vivo and in vitro mitochondrial respiration capacity in a subject with MELAS.
| MELAS | CTRL | ||
|---|---|---|---|
| PRE | POST | ||
| Body composition | |||
| Body mass (kg) | 36.2 | 37.6 | 70.7 ± 5.1 |
| Body fat (%) | 30.5 | 30.8 | 11.9 ± 2.5 |
| Thigh muscle mass (kg) | 2.11 | 2.21 | 6.85 ± 0.58 |
| Muscle function during 6 repetitions of isometric LE | |||
| MVC (Nm) | 48.8 ± 4.4 | 54.3 ± 1.1 | 173 ± 15.4 |
| EET (Nm) | 11.6 ± 1.5 | 13.7 ± 0.9 | 41 ± 6.3 |
| nMVC (Nm⋅kg-1) | 23.1 ± 2.1 | 24.6 ± 0.5 | 25.2 ± 0.8 |
| nEET (Nm⋅kg-1) | 5.5 ± 0.7 | 6.2 ± 0.4 | 6.4 ± 0.5 |
| VMA (%) | 68.2 ± 7.9 | 81.3 ± 4.9 | 94.2 ± 3.1 |
| In vivo mitochondrial respiration capacity | |||
| End exercise mVO2 (mM⋅min-1) | 1.99 | 2.01 | 9.82 ± 3.3 |
| Δ mVO2 (mM⋅min-1) | 1.71 | 1.79 | 8.61 ± 2.5 |
| τ mVO2 (s) | 94.7 | 24.5 | 21.3 ± 3.2 |
Data of the control participants (CTRL) and muscle function values are given as mean ± standard deviation. MELAS, Mitochondrial encephalomyopathy, lactic acidosis, and recurrent stroke-like episodes syndrome; MVC, maximal voluntary contraction; EET, electrical evoked twitch; nMVC, maximal voluntary contraction normalized by thigh muscle mass; nEET, electrical evoked twitch normalized by thigh muscle mass; VMA, voluntary activation; mVO2, muscle oxygen consumption.