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. 2018 Oct 31;29(4):288–297. doi: 10.1093/glycob/cwy093

Table II.

N-glycosylation acceptor sites that include the “DGGK” loop

Organism Phylum Sequence OST subunitsa
STT3
S. cerevisiae Fungi DNNTWNNT 8
H. sapiens (A) Metazoa DNNTWNNT 9
H. sapiens (B) Metazoa DNNTWNNS 8
D. melanogaster (A) Metazoa DNNTWNNT 9
D. melanogaster (B) Metazoa DNNTWNNT 8
O. sativa (A) Viridiplantae DNNTWNNT 9
O. sativa (B) Viridiplantae DNNTWNNT 8
T. vaginalis Parabasalia DGNTNNFT 4
E. histolytica Amoebozoa DNNTWNNS 4
T. thermophila Alveolata DNNTWNNT 5
P. falciparum Alveolata DNNTWNPE 4
C. parvum Alveolata DNNTWNNT 5
T. brucei Euglenozoa DGNTWNHE 1
L. major Euglenozoa DGNTWNHE 1
G. lamblia Diplomonadida DGLTRSTY 1
PglB
C. lari Proteobacteria DGGKHLGK 1
AglB
A. fulgidus Euryarchaeota NPFQAGIG 1
M. jannaschii Euryarchaeota DGGSQNSP 1
P. furiosus Euryarchaeota DGGHARDR 1
S. solfataricus Crenarchaeotab ENNTLNGT 1
P. calidifontis Crenarchaeotab DNSTINAT 1
M. yellowstonensis Crenarchaeotab ENNTLNDT 1
Bathyarchaeota sp.c Bathyarchaeotab DNGTINMT 1
N. viennensis Thaumarchaeotab DNATINQT 1
N. maritimus Thaumarchaeotab DNSTILDH 1
Odinarchaeota sp.c ASGARD DNGTFNQT 1
Thorarchaeota sp.c ASGARD DNATFNAT 1
N. equitans Nanoarchaeota DGGNYYPY 1

aSubunit compositions of OST complexes that have not been purified are based upon protein database searches. Four subunit complexes consist of STT3, WBP1, OST1 and OST2 while five subunit OST complexes in addition contain OST3. It is not known whether OST4 or OST5 are also present in the four or five subunit OST complexes as these small hydrophobic proteins can be overlooked in protein database searches.

bCrenarchaeota, Bathyarchaeota and Thaumarchaeota are part of the TACK superphylum.

cProtein sequences derived from DNA sequencing of uncultured organisms.