. 2019 Feb 26;8(1):CNS28. doi: 10.2217/cns-2018-0007

Table 3. . Summary of the proposed response assessment in neuro-oncology response criteria for low-grade gliomas.

Criterion	CR	PR	MR	SD	PD
T2/FLAIR	Disappearance of all lesions	≥50% ↓ in perpendicular diameters of lesion, sustained for 4 weeks	25–50% ↓ in perpendicular diameters of lesion	<25% ↓ to <25% ↑	≥25% ↑^†

New lesion	None (apart from those consistent with radiation effects, and no new or increased enhancement)	None (apart from those consistent with radiation effects, and no new or increased enhancement)	None (apart from those consistent with radiation effects, and no new or increased enhancement)	None (apart from those consistent with radiation effects, and no new or increased enhancement)	Present^†

Corticosteroids	None	Stable or ↓	Stable or ↓	Stable or ↓	NA^‡

Clinical status	Stable or ↑	Stable or ↑	Stable or ↑	Stable or ↑	↓^† (not attributable to other causes apart from the tumor, or decrease in corticosteroid dose)

Requirement for response	All	All	All	All	Any^‡

^†Progression occurs when this criterion is met.

^‡Increase in corticosteroids alone will not be taken into account in determining progression in the absence of persistent clinical deterioration.

↓: Decrease; ↑: Increase; CR: Complete response; FLAIR: Fluid-attenuated inversion recovery; MR: Minor response; NA: Not applicable; PD: Progressive disease; PR: Partial response; SD: Stable disease.