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. 2019 Apr 26;10:912. doi: 10.3389/fimmu.2019.00912

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Copyright © 2019 He, Zhao, Dai, Weng, Bian, Gong, Ge, Fang, Liu, Xu and Yin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Early cone synapse loss in the OPL during retinal degeneration in RCS rats. (A) Immunostaining for CtBP2 (green), mGluR6 (red) and cone arrestin (blue) in the retinas of control and RCS rats at P30. White arrows indicate cone synapses. (B–C) Quantification of the changes in the size of cone synaptic puncta positive for CtBP2 and mGluR6 in control and RCS rats at P15, P20, P30, P40, and P50 (N = 3–4 eyes from different rats, n = 9–15 images from each eye). (D) Quantification of the changes in the number of cone synapse in control and RCS rats at P15, P20, P30, P40, and P50 (N = 3–4 eyes from different rats, n = 9–15 images from each eye). Scale bar, 5 μm (A). Bars represent means; error bars represent SD. ^*p < 0.05, ^**p < 0.01, ^****p < 0.0001 using two-way ANOVA (B–D).