Table 2.
Demographics and neuropsychological characteristics of data sets for machine learning analyses.
| Mild Change (N = 461) |
Moderate Change (N = 435) |
Severe Change (N = 476) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Aβ + | Aβ - | Sig. | Aβ + | Aβ - | Sig. | Aβ + | Aβ - | Sig. | |
| (N = 183) | (N = 278) | (N = 232) | (N = 203) | (N = 322) | (N = 154) | ||||
| Age | 74.7 (6.7) | 71.8 (6.4) | 0.000 | 73.5 (6.8) | 71.1 (7.1) | 0.000 | 73.9 (7.5) | 71.3 (8.1) | 0.001 |
| Education | 16.0 (2.7) | 16.7 (2.4) | 0.003 | 16.3 (2.8) | 16.6 (2.4) | 0.162 | 16.0 (2.7) | 16.5 (2.4) | 0.044 |
| Gender: female | 98 (46%) | 131 (47%) | 0.177 | 114 (49%) | 95 (47%) | 0.626 | 144 (45%) | 65 (42%) | 0.605 |
| APOE 𝜀4: positive | 99 (54%) | 63 (23%) | 0.000 | 156 (67%) | 45 (22%) | 0.000 | 233 (72%) | 89 (59%) | 0.000 |
| LM Immediate Recall | 12.5 (3.3) | 13.4 (3.1) | 0.017 | 9.3 (4.0) | 11.6 (3.5) | 0.000 | 6.7 (3.9) | 9.7 (3.3) | 0.000 |
| LM Delayed Recall | 11 (3.2) | 12.2 (3.3) | 0.000 | 6.8 (4.3) | 9.7 (3.7) | 0.000 | 4.1 (3.7) | 7.3 (3.1) | 0.000 |
| AVLT Total | 40.9 (10.3) | 44.8 (11.1) | 0.005 | 35.5 (10.7) | 41.9 (11.6) | 0.000 | 29.2 (10.8) | 38.2 (12.2) | 0.000 |
| AVLT List B | 4.5 (1.9) | 5.3 (2.0) | 0.004 | 4.1 (1.8) | 4.9 (1.9) | 0.000 | 3.5 (1.7) | 4.6 (1.9) | 0.000 |
| AVLT Delayed Recall | 5.9 (3.9) | 7.4 (4.2) | 0.003 | 4.0 (3.9) | 6.4 (4.3) | 0.000 | 2.3 (3.2) | 5.3 (4.3) | 0.000 |
| AVLT Recognition | 12.1 (2.6) | 12.6 (2.6) | 0.125 | 10.8 (3.3) | 12.2 (2.8) | 0.000 | 8.9 (4.1) | 11.4 (3.2) | 0.000 |
| CLOCK Drawing | 4.5 (0.7) | 4.7 (0.6) | 0.331 | 4.4 (0.9) | 4.6 (0.7) | 0.045 | 3.9 (1.3) | 4.4 (0.9) | 0.000 |
| CLOCK Copy | 4.8 (0.5) | 4.8 (0.4) | 0.253 | 4.7 (0.7) | 4.8 (0.5) | 0.018 | 4.5 (0.9) | 4.7 (0.6) | 0.005 |
| Category Fluency (Animals) | 19.3 (5.6) | 20.5 (5.3) | 0.306 | 17.5 (5.4) | 19.5 (4.9) | 0.002 | 15 (5.7) | 18.5 (5.3) | 0.000 |
| Boston Naming Test | 27.4 (2.6) | 28.1 (2.5) | 0.070 | 26.3 (3.6) | 27.8 (2.5) | 0.000 | 24.3 (5.2) | 27 (3.5) | 0.000 |
| TMT A (seconds) | 37.1 (14.8) | 33.1 (11.3) | 0.028 | 40.3 (18.6) | 35.2 (13.5) | 0.012 | 49.5 (28.6) | 37.1 (14.1) | 0.000 |
| TMT B (seconds) | 98.3 (52.6) | 82.9 (44) | 0.069 | 114.5 (68) | 90.6 (47.4) | 0.002 | 138.7 (89.7) | 98.9 (58) | 0.000 |
| ANART (# of Errors) | 11.1 (8.6) | 9.8 (7.4) | 0.806 | 12.0 (9.5) | 11.3 (8.0) | 0.961 | 14.0 (9.8) | 12.1 (8.7) | 0.301 |
| MOCA | 23.6 (2.9) | 24.1 (1.9) | 0.142 | 23.2 (3.0) | 23.8 (2.0) | 0.070 | 21.3 (4.2) | 23.2 (2.8) | 0.000 |
| ADAS-Cog 13 | 12.0 (5.4) | 9.6 (4.9) | 0.000 | 16.4 (7.4) | 11.4 (5.7) | 0.000 | 22.9 (10.4) | 14.4 (7.7) | 0.000 |
| MMSE | 28.6 (1.5) | 28.9 (1.4) | 0.100 | 27.8 (1.8) | 28.7 (1.4) | 0.000 | 25.8 (3.0) | 27.9 (2.3) | 0.000 |
ADAS-Cog 13, 13 item version of the cognitive subscale of the Alzheimer’s Disease Assessment Scale-Cog; ANART, American National Adults Reading Test; APOE 𝜀4, apolipoprotein epsilon 4 allele carrier; AVLT, Rey Auditory Verbal Learning Test; LM, logical memory; MMSE, mini-mental status examination; MOCA, montreal cognitive assessment; TMT, Trail Making Test. Count (%) or mean (standard deviation). Comparisons for cognitive performances were adjusted for age, gender and education. P-values are from F-tests and Pearson chi-square tests. Significant p-values are highlighted in bold.