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. Author manuscript; available in PMC: 2020 Jan 1.
Published in final edited form as: Cephalalgia. 2018 May 31;39(1):123–134. doi: 10.1177/0333102418779557

Figure 5.

Figure 5.

Cutaneous facial allodynia following non-invasive dural application of IS is blocked by sumatriptan. Dural application of IS produced cutaneous facial hypersensitivity in female mice. Withdrawal thresholds to tactile stimuli applied to the face were measured in mice at the 3-hour time point following dural application of vehicle, IS, sumatriptan, or IS + sumatriptan (n = 6–9). A significant decrease in withdrawal threshold was observed only in the IS group. Significant differences among means for each group were determined by analysis of variance followed by Bonferroni post hoc test. Females facial: Treatment F (3, 26) = 5.408, p= 0.005.