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Mouse trigeminal ganglion neurons retrogradely labeled from the dura mater generate ASIC-like currents at pH 6.0. Recordings from retrogradely-labeled mouse dural afferents in response to a 5-sec pH change from 7.4 to 6.0 shown in (a) and (b) are characteristic of ASIC currents. (c) Current density (pA/pF) of the 13 neurons that responded to pH 6.0 (out of 20 total neurons recorded) range from 5–65 pA/pF with a mean of 22.5 pA/pF.
