Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Types of the hprt gene mutations detected in MSH6(+/+) and MSH6(−/−) cell lines
| Mutation type | Incidence
|
P value | |
|---|---|---|---|
| MSH6(+/+) | MSH6(−/−) | ||
| Base substitutions | 22 (44%) | 40 (80%) | <0.0002 |
| Transitions | 20 (40%) | 35 (70%) | <0.0026 |
| G⋅C → A⋅T | 13 (26%) | 32 (64%) | <0.0001 |
| A⋅T → G⋅C | 7 (14%) | 3 (6%) | |
| Transversions | 2 (4%) | 5 (10%) | |
| G⋅C → T⋅A | 2 (4%) | 5 (10%) | |
| Frameshifts | 28 (56%) | 10 (20%) | <0.0002 |
| +/−G | 24 (48%) | 8 (16%) | <0.0006 |
| +/−A | 4 (8%) | 0 (0%) | |
| +T | 0 (0%) | 1 (2%) | |
| −CA | 0 (0%) | 1 (2%) | |
