Figure 1.

CD8 and CD4 T cells from GM treated patients have increased effector memory T cell compartment associated with a decreased central memory one as compared to both GM untreated patients and HC group. Representatives of CD8 (A) and CD4 (C) T cell subsets from one GM treated RA patient, one GM untreated patient and a gender- and age-matched control individual. CD8 and CD4 T cells were subgrouped into naïve (T_N), effector (T_E), central memory (T_CM) and effector memory (T_EM) subpopulations by using anti-CD45RA and anti-CCR7 antibodies. Pooled data of T_N, T_E, T_CM, and T_EM subpopulations in CD8 (B) and CD4 (D) T cells from GM untreated patients (n = 23), GM treated patients (n = 14) and control individuals (n = 68). Horizontal lines indicate mean values.