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. 2019 Apr 24;10:887. doi: 10.3389/fimmu.2019.00887

Figure 2.

Figure 2

Increased cytokine production in CD8+CD45RA and CD4+CD45RA T cells in GM treated patients. Freshly isolated PBMCs were stimulated with PMA/Iono for 6 h and IFNγ, TNFα, IL-2, and IL-17 production were detected by intracellular cytokine staining. (A,C) representatives of ICS analysis of CD8 and CD4 T cells from HC, GM untreated and GM treated RA patients. (B) Statistical analysis of IFNγ, TNFα, IL-2, and IL-17 secreting CD8 TM cells in GM untreated patients (n = 21), GM treated patients (n = 14) and control individuals (n = 68). (D) Statistical analysis of IFNγ, TNFα, IL-2, and IL-17 secreting CD4 TM cells from GM untreated patients (n = 21), GM treated patients (n = 14) and control individuals (n = 68).