Table 5.
regulations of SEs by tumor-associated viruses.
| Virus† | Phenotype‡ | Upstream (O/S) and potential therapeutic targets§ | Regulation of SEs | Downstream | References |
|---|---|---|---|---|---|
| HPV | P | BETi: JQ1, iBET72 (S) | ↓ | E6 and E7 | Dooley et al., 2016 |
| HPV | NM | KDM5C (S) | ↓ | EGFR, c-MET | Chen et al., 2018 |
| HPV | NM | NM | SELE formation | E6/E7 | Warburton et al., 2018 |
| EBV | G | EBNA2 (O) | ↑ | RUNX3, RUNX1 | Gunnell et al., 2016 |
| EBV | P, G | EBV nuclear antigens (O) | ↑ | MCL1, IRF4, EBF, MYC | Jiang S. et al., 2017 |
†Abbreviation for viruses: EBV, Epstein-Barr virus; HPV, human papillomavirus. ‡Abbreviation for phenotypes: G, growth; NM, not mentioned; P, proliferation. §Abbreviation for molecules: BETi, Bromodomain inhibitor; NM, not mentioned; O, oncogenic molecule; S, suppressor of cancer; SELE, super-enhancer-like element.