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. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783

Figure 3.

Figure 3

Lack of PD-1 signaling augments CD8 T cell IFN-γ production in vivo. (A) Representative histograms of MHC class II expression on microglia from WT and PD-L1−/− mice at 8 dpi (left panel) with mean ± SD of MHC II gMFI (right panel). (B) MHC II gMFI (mean ± SD) on microglia at 45 dpi. (C) MHC II gMFI on microglia from WT mice at 8 dpi after i.v. transfer of IFN-γ sufficient or IFN-γ−/− naïve TCR-I cells at day−1. Combined data from 2 to 3 independent experiments with 2–4 mice per group; each value indicates cells isolated from an individual mouse. Two-way ANOVA with Tukey multiple comparison test (A) or Mann Whitney test (C) was performed. **p ≤ 0.01.