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. 2019 Apr 17;10:783. doi: 10.3389/fimmu.2019.00783

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Copyright © 2019 Shwetank, Frost, Mockus, Ren, Toprak, Lauver, Netherby-Winslow, Jin, Cosby, Evavold and Lukacher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PD-1 signaling alters inflammatory pathways in the brain during MuPyV infection. Pathway enrichment analysis of the differentially expressed genes between MuPyV-infected WT vs. mock-inoculated WT control (left panel), and MuPyV-infected PD-L1^−/− vs. mock-inoculated PD-L1^−/− control brain (right panel) at 8 dpi (A) and 35 dpi (B) using IPA software. The y-axis represents pathway and the x-axis represents enrichment ratio. Bubble size represents the z-score and color represents the -log(p-value) calculated by Fisher's exact test.