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. 2019 Apr 18;10:353. doi: 10.3389/fgene.2019.00353

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Copyright © 2019 Xiong, Tu, Yan, Xiao, Yao, Li, Yang, Zhou, Liu, Hu and Zhu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Photographic features of hands and feet in the affected individuals. Abnormal joint osseous fusion in fingers and difficulties in making fists were seen in all of patients II-4 (a,b), I-2 (e,f) and II-1 (j,k). For patient II-4, the motion of the elbow joint is normal (c), and a little short phalange of second toe is noticed in both her feet (d). Radiographs of the hands reveal that patient I-2 (g) and II-1 (l) have proximal symphalangism in hands. Radiographs of right feet in anteroposterior and oblique view show that patient I-2 (h,i) presents proximal symphalangism in toes and tarsal coalitions, while patient II-1 (m,n) has both proximal and distal symphalangism in toes and tarsal coalition.