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Predicted effect of the c.163G > T (p.Asp55Tyr) on noggin protein structure by multiple algorithms.
| Algorithm | Predicted effect | Score |
|---|---|---|
| SIFT | Deleterious | 0.005 |
| MutationTaster | Disease causing | 0.818 |
| LRT | Deleterious | 0.8932 |
| Fathmm | Damaging | 0.9839 |
SIFT, Sorting Intolerant From Tolerant (Ng and Henikoff, 2003); MutationTaster (Schwarz et al., 2010); LRT, Likelihood Ratio Test (Chun and Fay, 2009); Fathmm, Functional Analysis through Hidden Markov Models (Shihab et al., 2013).
