Table 1.
Biochemical and metabolic effects of T (T) deficiency and their reversal after T replacement therapy (TRT).
| Low T | TRT | ||
|---|---|---|---|
| HDL cholesterol | ↓ | ↓ | (Smaller ↓ observed in older men) |
| Total cholesterol | ↑ | ↓ | Total cholesterol |
| LDL cholesterol | ↑ | ↓ | LDL cholesterol |
| Triglycerides | ↑ | ↓ | Apoprotein B |
| ↓ | Lipoprotein a | ||
| Hypertension | ↑ | ↓ | Diastolic BP by 4–5 mmHg |
| Fibrinogen | ↑ | ↓ | Fibrinogen |
| PAI-1 | ↑ | ↓ | PAI-1 |
| Visceral obesity | ↑ | ↓ | Visceral obesity |
| Fasting glucose | ↑ | ↑ | Insulin sensitivity |
| Fasting insulin | ↑ | ↓ | Insulin resistance |