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. 2019 Apr 17;10:814. doi: 10.3389/fimmu.2019.00814

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Copyright © 2019 Yu, Gao, Wang, Yin, Fang, Chen, Li, Xu and Gui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Longitudinal changes on gray matter volume (GMV) after 1 year. Clusters showing significantly (corrected P < 0.05) lower (blue) and higher (red) GMV changes after 1 year. (A) Clusters showing many lower and few higher GMV regions in HIV+ group children. (B) Clusters only showing significantly lower GMV regions in HEU group children. (C) Put together the two groups for statistical analysis and showing significantly changes of GMV after 1 year. (D) In assessing the time and interactions between the two groups, clusters showing widely areas of GMV significantly reduced. These figures were rendered using BrainNet Viewer (http://www.nitrc.org/projects/bnv/).