Table 1.
Drugs Absolutely Contraindicated With the Prescription of Telaprevir or Boceprevir Because of Potentially Serious Adverse Events
| Drug Class | Examples | Potentially Serious or Life‐Threatening Adverse Events |
|---|---|---|
| CYP3A substrates/inhibitors | ||
| Alpha‐1‐adrenoreceptor antagonists | Alfuzosin | Hypotension, dizziness |
| Ergot derivatives | Dihydroergotamine Ergonovine Ergotamine Methylergonovine | Peripheral vasospasm or ischemia |
| Gastrointestinal motility agents | Cisapride | Cardiac arrhythmia, QT prolongation |
| 3‐Hydroxy‐3‐methyl‐ glutaryl‐coenzyme A reductase inhibitors (statins) | Atorvastatin* Lovastatin Simvastatin | Myopathy, rhabdomyolysis |
| Neuroleptics | Pimozide | Cardiac arrhythmia |
| Oral contraceptives† | Drospirenone | Hyperkalemia |
| Phosphodiesterase type 5 enzyme inhibitors† | Sildenafil Tadalafil | Visual abnormalities, hypotension, prolonged erection, syncope |
| Sedatives | Midazolam Triazolam | Prolonged sedation, respiratory depression |
| CYP3A inducers | ||
| Anticonvulsants† | Carbamazepine Phenobarbital Phenytoin | Reduced DAA levels with potentially reduced antiviral efficacy and increased drug resistance |
| Antimycobacterials | Rifampin | |
| Herbal products | St. John's wort | |