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. 2019 May 1;33(9-10):479–481. doi: 10.1101/gad.325761.119

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© 2019 Harris and Guillemot; Published by Cold Spring Harbor Laboratory Press

This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/.

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Figure 1. — HES1 and ASCL1 expression dynamics in embryonic and adult NSCs. (A) NSC proliferation in the ventral telencephalon is orchestrated by the oscillatory expression patterns of the Notch effector HES1 and its target, ASCL1, with subsequent Notch inhibition and stabilization of ASCL1 driving neuronal differentiation. (B) Adult NSCs are primarily quiescent. Sueda et al. (2019) demonstrate that Notch promotes both the quiescent and proliferative states of adult NSCs through regulating the levels and expression dynamics of HES1. (IPC) Intermediate progenitor cell.