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. 2019 May 1;33(9-10):565–577. doi: 10.1101/gad.320440.118

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© 2019 Leopold et al.; Published by Cold Spring Harbor Laboratory Press

This article, published in Genes & Development, is available under a Creative Commons License (Attribution 4.0 International), as described at http://creativecommons.org/licenses/by/4.0/.

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Figure 4. — The Mit1 CkIvV motif also binds Swi6. (A) Heat rates and fit for ITC experiment where Swi6CSD is injected into a solution of Mit1CII. (B) Surface representation of Swi6 and Chp2 superimposed as in Supplemental Figure S4A shows that critical interactions in the extended interaction interface of Mit1 are blocked or are missing on the Swi6 surface. (C) Model of the Mit1 CkIvV motif in the CSD dimerization groove of Swi6. (D) The high-affinity Chp2–Mit1 interaction uncouples Mit1/SHREC recruitment to H3K9 methyl marks from Swi6. Schematic representation of the SHREC complex with the Chp2–Mit1 structure shown in surface representation summarizing the current structural knowledge on the complex (Job et al. 2016).