Figure 1:

Prenatal stress induces anxiety-like behavior in adult offspring at age of postnatal day 75 (PND75). Anxiety-like behaviors were measured using the elevated plus maze (EPM) and Light/Dark Box (LDB) tests. Compared with NS mice, PRS mice exhibited low percentage of entering into, and time spent in open arms in EPM test (A), high preference to dark compartment in LDB test (B) and similar ambulation of LDB exploration (C) Data are presented as mean ± SEM. For EPM, *p < 0.05 (open arm entries), **p < 0.01 (duration in open arms) vs. NS mice, respectively, N= 8 for each group. For LDB, *p < 0.05, NS vs PRS mice, N= 8 for each group.