Table 1.

Review framework according to the CHARMS checklist

Item	Criterion
Prognostic or diagnostic	Prognostic, i.e., future events.
Scope	Prognostic models to inform clinicians (and general population) about the risk of a person to develop a nonfatal/fatal cardiovascular event in a pre-defined period.
Type of prediction models	Prognostic models with and/or without external validation.
Prediction target population	General population, men and women.
Outcome of interest	Any nonfatal or fatal cardiovascular event, including myocardial infarction, stroke, or cardiovascular death; these outcomes could have been studied independently or as a composite endpoint.
Prediction period	Any (e.g., 10 yrs).
Intended moment to apply the prediction tool	Prognostic tool to be used in primary prevention to assess cardiovascular risk and thus guide prevention/treatment.

CHARMS, CHecklist for critical Appraisal and data extraction for systematic Reviews of prediction Modelling Studies.