Table 1. Associations between tissue HMGB1 expression and clinicopathologic characteristics of cervical cancer patients.
| Variables | HMGB1 expression (n (%)) | Total N | χ2 | P-value | |
|---|---|---|---|---|---|
| High 5–7 | Low 0–4 | ||||
| Age at diagnosis (years) | 0.262 | 0.609 | |||
| <40 | 47 (57.3) | 35 (42.7) | 82 | ||
| ≥40 | 84 (53.5) | 73 (46.5) | 157 | ||
| Tumor size | 8.627 | 0.003 | |||
| <4cm | 60 (46.2) | 70 (53.8) | 130 | ||
| ≥4cm | 71 (65.1) | 38 (34.9) | 109 | ||
| Vascular invasion | 0.291 | 0.589 | |||
| Yes | 53 (57.0) | 40 (43.0) | 93 | ||
| No | 78 (53.4) | 68 (46.7) | 146 | ||
| Parametrial infiltration | 5.459 | 0.019 | |||
| Yes | 17 (73.9) | 6 (26.1) | 23 | ||
| No | 11 (52.8) | 102 (47.2) | 216 | ||
| Histological subtype | 0.311 | 0.577 | |||
| Squamous cell carcinoma | 112 (54.1) | 95 (45.9) | 207 | ||
| Adenocarcinoma | 19 (59.4) | 13 (40.6) | 32 | ||
| Histopathologic grade | 2.463 | 0.292 | |||
| G1 | 31 (46.3) | 36 (53.7) | 67 | ||
| G2 | 43 (38.7) | 68 (61.3) | 111 | ||
| G3 | 20 (32.8) | 41 (67.2) | 61 | ||
| Depth of cervical stromal invasion | 6.130 | 0.013 | |||
| <1/2 | 59 (47.2) | 66 (53.8) | 125 | ||
| ≥1/2 | 72 (63.2) | 42 (36.8) | 114 | ||
| FIGO stage | 8.988 | 0.003 | |||
| I | 71 (47.0) | 80 (53.0) | 151 | ||
| II | 60 (67.0) | 28 (37.0) | 88 | ||
| Lymph node metastasis | 0.258 | 0.612 | |||
| Yes | 20 (58.8) | 14 (41.2) | 34 | ||
| No | 111 (54.1) | 94 (45.9) | 205 | ||