Figure 1.

Volume response NTCP models for brain necrosis. (a) For Grade 1–3 edema or necrosis and (b) for Grade 3 surgically removed and pathologically confirmed necrosis. NTCP = Normal tissue complication probability, GTV = Gross tumor volume, cc = Cubic centimeters, 1fx = Single-fraction equivalent dose using linear quadratic with α/β =2 Gy, V14Gy = The volume of total brain exceeding an equivalent dose of 14 Gy in one fraction, AE = Adverse event, MLE = Maximum likelihood estimate