Fig 1.

Blood lactate concentration (mmol/L) during rest and immediately post-exercise at increasing running speeds (m/min) in female nude NCr nu/nu mice (n = 5) at a 10-degree incline after 60 minutes of running (1A); after 30 minutes of running in female NCr nu/nu mice (1B) and after 30 minutes of running in female nude NMRI mice (1C). Points represent individual mice. 1A and 1B involved the use of air puffs to encourage mice to run, whereas 1C involved gentle prodding and physical handling. Statistical change (one-way ANOVA, p-value) in lactate concentration with increasing speed is displayed in each Fig. * indicates significant difference compared to the resting value (Student´s t-test, p<0.05). Specific p-value above line indicates significant difference compared to value at the previous running speed (Students t-test, p<0.05). If applicable, the mean number of times paced are reported above the x-axis.