Table 3.

Risk of Death or Nonfatal Heart Failure Events During Long-Term Follow-Up Associated With Increasing Comorbidity Burden for Patients With CRT-D vs. ICD Only

Comorbidity Group	Event Rate	Unadjusted HR* (95% CI)	Adjusted† HR* (95% CI)	p Value‡
0	15 (22/147)	0.56 (0.24–1.30)	0.51 (0.22–1.17)	0.113
1	23 (71/304)	0.48 (0.30–0.76)	0.50 (0.31–0.81)	0.005
2	28 (91/324)	0.38 (0.25–0.58)	0.44 (0.28–0.68)	<0.001
≥3	40 (177/439)	0.53 (0.39–0.71)	0.52 (0.38–0.70)	<0.001
Interaction p-value	0.943

Values are % (n/N) unless otherwise indicated.

HR = hazard ratio; other abbreviations as in Tables 1 and 2.

^*Representing hazard of death or nonfatal heart failure events in the group with CRT-D compared with the group with ICD only.

^†Model adjusted for age, sex, baseline LVESV, QRS interval, and PR duration.

^‡Interaction p = 0.943.